Aptamer-based detection of disease biomarkers in mouse models for chagas drug discovery.

• Main Authors: Fernanda Fortes de Araujo (Author), Rana Nagarkatti (Author), Charu Gupta (Author), Ana Paula Marino (Author), Alain Debrabant (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug discovery initiatives, aimed at Chagas treatment, have been hampered by the lack of standardized drug screening protocols and the absence of simple pre-clinical assays to evaluate treatment efficacy in animal models. In this study, we used a simple Enzyme Linked Aptamer (ELA) assay to detect T....