Beta-Blockers and Oxidative Stress in Patients with Heart Failure

• Main Authors: Kazufumi Nakamura (Author), Kenki Enko (Author), Kei Yunoki (Author), Daiji Miura (Author), Masato Murakami (Author), Hiroshi Ito (Author), Tohru Ohe (Author), Hiromi Matsubara (Author), Kengo F Kusano (Author), Hiroshi Morita (Author), Kunihisa Kohno (Author), Satoshi Nagase (Author), Norihisa Toh (Author), Masashi Yoshida (Author), Hiroki Oe (Author), Toru Miyoshi (Author), Nobuhiro Nishii (Author), Yukihiro Saito (Author), Masamichi Tanaka (Author)
• Format: Book
• Published: MDPI AG, 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress has been implicated in the pathogenesis of heart failure. Reactive oxygen species (ROS) are produced in the failing myocardium, and ROS cause hypertrophy, apoptosis/cell death and intracellular Ca2+ overload in cardiac myocytes. ROS also cause damage to lipid cell membranes in the p...