A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

• Main Authors: Daniel Scotcher (Author), Vikram Arya (Author), Xinning Yang (Author), Ping Zhao (Author), Lei Zhang (Author), Shiew‐Mei Huang (Author), Amin Rostami‐Hodjegan (Author), Aleksandra Galetin (Author)
• Format: Book
• Published: Wiley, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Creatinine is the most common clinical biomarker of renal function. As a substrate for renal transporters, its secretion is susceptible to inhibition by drugs, resulting in transient increase in serum creatinine and false impression of damage to kidney. Novel physiologically based models for creatin...