Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation

• Κύριοι συγγραφείς: Li Lu (Συγγραφέας), Li Zhitao (Συγγραφέας), Cui Nannan (Συγγραφέας), Huang Mingzhu (Συγγραφέας), Hu Xiaoping (Συγγραφέας), Hong Dongsheng (Συγγραφέας), Pan Zongfu (Συγγραφέας), Lu Xiaoyang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Hindawi Limited, 2022-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

β cell dysfunction is the leading cause of diabetes. Adult β cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal β cells are insensitive to glucose and are functionally immature. However, how β cells mature and acquire robust GSIS is not fully understood. Here,...