Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation

• Egile Nagusiak: Li Lu (Egilea), Li Zhitao (Egilea), Cui Nannan (Egilea), Huang Mingzhu (Egilea), Hu Xiaoping (Egilea), Hong Dongsheng (Egilea), Pan Zongfu (Egilea), Lu Xiaoyang (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2022-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

β cell dysfunction is the leading cause of diabetes. Adult β cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal β cells are insensitive to glucose and are functionally immature. However, how β cells mature and acquire robust GSIS is not fully understood. Here,...