Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation

• Main Authors: Li Lu (Author), Li Zhitao (Author), Cui Nannan (Author), Huang Mingzhu (Author), Hu Xiaoping (Author), Hong Dongsheng (Author), Pan Zongfu (Author), Lu Xiaoyang (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

β cell dysfunction is the leading cause of diabetes. Adult β cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal β cells are insensitive to glucose and are functionally immature. However, how β cells mature and acquire robust GSIS is not fully understood. Here,...