Lysoquinone-TH1, a New Polyphenolic Tridecaketide Produced by Expressing the Lysolipin Minimal PKS II in Streptomyces albus

• Main Authors: Torben Hofeditz (Author), Claudia Eva-Maria Unsin (Author), Jutta Wiese (Author), Johannes F. Imhoff (Author), Wolfgang Wohlleben (Author), Stephanie Grond (Author), Tilmann Weber (Author)
• Format: Book
• Published: MDPI AG, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The structural repertoire of bioactive naphthacene quinones is expanded by engineering Streptomyces albus to express the lysolipin minimal polyketide synthase II (PKS II) genes from Streptomyces tendae Tü 4042 (llpD-F) with the corresponding cyclase genes llpCI-CIII. Fermentation of the rec...