Responsiveness of rat aorta and pulmonary artery to cGMP generators in the presence of thiol or heme oxidant

• Main Authors: Masashi Tawa (Author), Yuka Yamashita (Author), Takayoshi Masuoka (Author), Katsuya Nakano (Author), Junko Yoshida (Author), Matomo Nishio (Author), Takaharu Ishibashi (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigated the effects of thiol and heme oxidants on responsiveness to cGMP generators in isolated rat aorta and pulmonary artery using an organ chamber. The nitric oxide (NO) donor sodium nitroprusside (SNP)-induced relaxation was impaired by exposure to the thiol oxidant diamide in bo...