Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A

• Main Authors: Muhammad Rafehi (Author), Frank Faltraco (Author), Johannes Matthaei (Author), Thomas Prukop (Author), Ole Jensen (Author), Aileen Grytzmann (Author), Felix G. Blome (Author), Ralf Günter Berger (Author), Ulrich Krings (Author), Stefan V. Vormfelde (Author), Mladen V. Tzvetkov (Author), Jürgen Brockmöller (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tyramine, formed by the decarboxylation of tyrosine, is a natural constituent of numerous food products. As an indirect sympathomimetic, it can have potentially dangerous hypertensive effects. In vitro data indicated that the pharmacokinetics of tyramine possibly depend on the organic cation transpo...