Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling

• Main Authors: Li-Hua Cao (Author), Yuan-Yuan Zhao (Author), Ming Bai (Author), David Geliebter (Author), Jan Geliebter (Author), Raj Tiwari (Author), Hong-Juan He (Author), Zhen-zhen Wang (Author), Xing-Yuan Jia (Author), Jin Li (Author), Xiu-Min Li (Author), Ming-San Miao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depression is a prevalent psychiatric disorder. Microglial state transition has been found in many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII, Gps) are saponin extracts isolated from the traditional Chinese herb Gynostemma pentaphyllum (Thunb.) Makino that exert...