Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid

• Main Authors: Safiye E. Sarper (Author), Toshihiro Inubushi (Author), Hiroshi Kurosaka (Author), Hitomi Ono Minagi (Author), Yuka Murata (Author), Koh-ichi Kuremoto (Author), Takayoshi Sakai (Author), Ichiro Taniuchi (Author), Takashi Yamashiro (Author)
• Format: Book
• Published: The Company of Biologists, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Core binding factor β (Cbfb) is a cofactor of the Runx family of transcription factors. Among these transcription factors, Runx1 is a prerequisite for anterior-specific palatal fusion. It was previously unclear, however, whether Cbfb served as a modulator or as an obligatory factor in the Runx signa...