Genes Related to Mitochondrial Functions, Protein Degradation, and Chromatin Folding Are Differentially Expressed in Lymphomonocytes of Rett Syndrome Patients

• Main Authors: Alessandra Pecorelli (Author), Guido Leoni (Author), Franco Cervellati (Author), Raffaella Canali (Author), Cinzia Signorini (Author), Silvia Leoncini (Author), Alessio Cortelazzo (Author), Claudio De Felice (Author), Lucia Ciccoli (Author), Joussef Hayek (Author), Giuseppe Valacchi (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rett syndrome (RTT) is mainly caused by mutations in the X-linked methyl-CpG binding protein (MeCP2) gene. By binding to methylated promoters on CpG islands, MeCP2 protein is able to modulate several genes and important cellular pathways. Therefore, mutations in MeCP2 can seriously affect the cellul...