Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

• Main Authors: Lukas Zanders (Author), Melanie Kny (Author), Alexander Hahn (Author), Sibylle Schmidt (Author), Sebastian Wundersitz (Author), Mihail Todiras (Author), Ines Lahmann (Author), Arnab Bandyopadhyay (Author), Tobias Wollersheim (Author), Lars Kaderali (Author), Friedrich C. Luft (Author), Carmen Birchmeier (Author), Steffen Weber‐Carstens (Author), Jens Fielitz (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway, but its role in sepsis‐induced muscl...