Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib

• Main Authors: Hye-In Kim (Author), Sang Yeob Park (Author), Seok Ju Park (Author), Jewon Lee (Author), Kwan Hyung Cho (Author), Jun-Pil Jee (Author), Hee-Cheol Kim (Author), Han-Joo Maeng (Author), Dong-Jin Jang (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aims at developing and evaluating reconstitutable dry suspension (RDS) improved for dissolution rate, oral absorption, and convenience of use of poorly water-soluble celecoxib (CXB). Micro-sized CXB particle was used to manufacture nanosuspension by using bead milling and then RDS was mad...