Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K‐Akt-mTOR pathway

• Main Authors: Huaqing Chen (Author), Tong Zhu (Author), Xiaojie Huang (Author), Wenshuang Xu (Author), Zemin Di (Author), Yuyang Ma (Author), Min Xue (Author), Sixing Bi (Author), Yujun Shen (Author), Yongqiang Yu (Author), Yuxian Shen (Author), Lijie Feng (Author)
• Format: Book
• Published: Wiley, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Glioma is the most common and aggressive primary brain tumor in adults with high morbidity and mortality. Rapid proliferation and diffuse migration are the main obstacles to successful glioma treatment. Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses a sig...