Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway

• Asıl Yazarlar: Yuan Zhao (Yazar), Xiujing Feng (Yazar), Bei Li (Yazar), Jichen Sha (Yazar), Chaoran Wang (Yazar), Tianyuan Yang (Yazar), Hailin Cui (Yazar), Honggang Fan (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

BackgroundAcute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renoprote...