Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway

BackgroundAcute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renoprote...

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Main Authors: Yuan Zhao (Author), Xiujing Feng (Author), Bei Li (Author), Jichen Sha (Author), Chaoran Wang (Author), Tianyuan Yang (Author), Hailin Cui (Author), Honggang Fan (Author)
Format: Book
Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
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