Therapeutic Potential of the Cyclin-Dependent Kinase Inhibitor Flavopiridol on c-Myc Overexpressing Esophageal Cancer

• Päätekijät: Md Sazzad Hassan (Tekijä), Nicholas Cwidak (Tekijä), Chloe Johnson (Tekijä), Silvio Däster (Tekijä), Serenella Eppenberger-Castori (Tekijä), Niranjan Awasthi (Tekijä), Jun Li (Tekijä), Margaret A. Schwarz (Tekijä), Urs von Holzen (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Tumors with elevated c-Myc expression often exhibit a highly aggressive phenotype, and c-Myc amplification has been shown to be frequent in esophageal cancer. Emerging data suggests that synthetic lethal interactions between c-Myc pathway activation and small molecules inhibition involved in cell cy...