Therapeutic Potential of the Cyclin-Dependent Kinase Inhibitor Flavopiridol on c-Myc Overexpressing Esophageal Cancer

• Váldodahkkit: Md Sazzad Hassan (Dahkki), Nicholas Cwidak (Dahkki), Chloe Johnson (Dahkki), Silvio Däster (Dahkki), Serenella Eppenberger-Castori (Dahkki), Niranjan Awasthi (Dahkki), Jun Li (Dahkki), Margaret A. Schwarz (Dahkki), Urs von Holzen (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Tumors with elevated c-Myc expression often exhibit a highly aggressive phenotype, and c-Myc amplification has been shown to be frequent in esophageal cancer. Emerging data suggests that synthetic lethal interactions between c-Myc pathway activation and small molecules inhibition involved in cell cy...