CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

• Hlavní autoři: Astrid Drenckhan (Autor), Morton Freytag (Autor), Claudiu T. Supuran (Autor), Guido Sauter (Autor), Jakob R. Izbicki (Autor), Stephanie J. Gros (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Témata: article
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The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under hypoxia. We show that CAIX is strongly expressed i...