Population pharmacokinetic modeling of daridorexant, a novel dual orexin receptor antagonist

• मुख्य लेखकों: Andreas Krause (लेखक), Dominik Lott (लेखक), Janneke M. Brussee (लेखक), Clemens Muehlan (लेखक), Jasper Dingemanse (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract The analysis aimed at identifying subject‐specific characteristics (covariates) influencing exposure to daridorexant and quantification of covariate effects to determine clinical relevance. Data from 13 phase I, two phase II, and two phase III studies were pooled to develop a population pha...