Population pharmacokinetic modeling of daridorexant, a novel dual orexin receptor antagonist

• Asıl Yazarlar: Andreas Krause (Yazar), Dominik Lott (Yazar), Janneke M. Brussee (Yazar), Clemens Muehlan (Yazar), Jasper Dingemanse (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2023-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract The analysis aimed at identifying subject‐specific characteristics (covariates) influencing exposure to daridorexant and quantification of covariate effects to determine clinical relevance. Data from 13 phase I, two phase II, and two phase III studies were pooled to develop a population pha...