Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats

• Main Authors: Bin Hu (Author), Tian Tian (Author), Xin-Tao Li (Author), Pei-Pei Hao (Author), Wei-Chao Liu (Author), Ying-Gui Chen (Author), Tian-Yu Jiang (Author), Pei-Shan Chen (Author), Yi Cheng (Author), Fu-Shan Xue (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTObjectives To observe the protective effects of dexmedetomidine (Dex) postconditioning on myocardial ischemia/reperfusion injury (IRI) and to explore its potential molecular mechanisms.Methods One-hundred forty-seven male Sprague-Dawley rats were randomly divided into five groups receiving t...