A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models

• Main Authors: Ming Ji (Author), Dongjie Wang (Author), Songwen Lin (Author), Chunyang Wang (Author), Ling Li (Author), Zhihui Zhang (Author), Jing Jin (Author), Deyu Wu (Author), Yi Dong (Author), Heng Xu (Author), Duo Lu (Author), Xiaoguang Chen (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors. Brain metastasis, such as breast cancer and lung cancer, also leads to high mortality. The available medicines are limited due to blood-brain barrier. Abnormal activation...