Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability

• Main Authors: Miriam Hoene (Author), Lisa Kappler (Author), Laxmikanth Kollipara (Author), Chunxiu Hu (Author), Martin Irmler (Author), Daniel Bleher (Author), Christoph Hoffmann (Author), Johannes Beckers (Author), Martin Hrabě de Angelis (Author), Hans-Ulrich Häring (Author), Andreas L. Birkenfeld (Author), Andreas Peter (Author), Albert Sickmann (Author), Guowang Xu (Author), Rainer Lehmann (Author), Cora Weigert (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Liver mitochondria adapt to high-calorie intake. We investigated how exercise alters the early compensatory response of mitochondria, thus preventing fatty liver disease as a long-term consequence of overnutrition. Methods: We compared the effects of a steatogenic high-energy diet (HED) f...