Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

Good pharmacokinetic (PK) behavior is a key prerequisite for sufficient efficacy of therapeutic monoclonal antibodies (mAbs). Fc glycosylation is a critical quality attribute (CQA) of mAbs, due to its impact on stability and effector functions. However, the effects of various IgG Fc glycoforms on an...

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主要な著者: David Falck (著者), Marco Thomann (著者), Martin Lechmann (著者), Carolien A. M. Koeleman (著者), Sebastian Malik (著者), Cordula Jany (著者), Manfred Wuhrer (著者), Dietmar Reusch (著者)
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出版事項: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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