Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

• Main Authors: David Falck (Author), Marco Thomann (Author), Martin Lechmann (Author), Carolien A. M. Koeleman (Author), Sebastian Malik (Author), Cordula Jany (Author), Manfred Wuhrer (Author), Dietmar Reusch (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Good pharmacokinetic (PK) behavior is a key prerequisite for sufficient efficacy of therapeutic monoclonal antibodies (mAbs). Fc glycosylation is a critical quality attribute (CQA) of mAbs, due to its impact on stability and effector functions. However, the effects of various IgG Fc glycoforms on an...