A Metabolomics Approach for Predicting OATP1B-Type Transporter-Mediated Drug-Drug Interaction Liabilities

• Glavni autori: Yang Li (Autor), Yan Jin (Autor), Hanieh Taheri (Autor), Keith T. Schmidt (Autor), Alice A. Gibson (Autor), Stefan A. J. Buck (Autor), Eric D. Eisenmann (Autor), Ron H. J. Mathijssen (Autor), William D. Figg (Autor), Sharyn D. Baker (Autor), Alex Sparreboom (Autor), Shuiying Hu (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2022-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

In recent years, various endogenous compounds have been proposed as putative biomarkers for the hepatic uptake transporters OATP1B1 and OATP1B3 that have the potential to predict transporter-mediated drug-drug interactions (DDIs). However, these compounds have often been identified from top-down str...