Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells

• Main Authors: Yi Zhang (Author), Roslyn Tedja (Author), Michael Millman (Author), Terrence Wong (Author), Alexandra Fox (Author), Hussein Chehade (Author), Meyer Gershater (Author), Nicholas Adzibolosu (Author), Radhika Gogoi (Author), Matthew Anderson (Author), Thomas Rutherford (Author), Zhenggang Zhang (Author), Michael Chopp (Author), Gil Mor (Author), Ayesha B. Alvero (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene silencer. Our group has previously reported that CBX7 functions as a tumor suppressor in ovarian cancer cells and its loss accelerated formation of carcinomat...