Synthesis and Immunological Evaluation of Virus-Like Particle-Milbemycin A3/A4 Conjugates

• Main Authors: Andris Zeltins (Author), Māris Turks (Author), Dace Skrastina (Author), Jevgeņija Lugiņina (Author), Ieva Kalnciema (Author), Ina Balke (Author), Ērika Bizdēna (Author), Vitalijs Skrivelis (Author)
• Format: Book
• Published: MDPI AG, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Milbemycins are macrolide antibiotics with a broad spectrum of nematocidal, insecticidal, and acaricidal activity. To obtain milbemycin A3/A4 derivatives suitable for chemical conjugation to protein carriers (milbemycin haptens), succinate linker and a novel 17-atom-long linker containing a terminal...