Phenotypic whole-cell screening identifies a protective carbohydrate epitope on Klebsiella pneumoniae

• Main Authors: Sophia K. Berry (Author), Steven Rust (Author), Carolina Caceres (Author), Lorraine Irving (Author), Josefin Bartholdson Scott (Author), David E. Tabor (Author), Gordon Dougan (Author), Graham Christie (Author), Paul Warrener (Author), Ralph Minter (Author), Andrew J. Grant (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The increasing global occurrence of recalcitrant multi-drug resistant Klebsiella pneumoniae infections warrants the investigation of alternative therapy options, such as the use of monoclonal antibodies (mAbs). We used a target-agnostic phage display approach to K. pneumoniae bacteria lacking bulky,...