R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency

• Main Authors: Justine Bouilly (Author), Isabelle Beau (Author), Sara Barraud (Author), Valérie Bernard (Author), Brigitte Delemer (Author), Jacques Young (Author), Nadine Binart (Author)
• Format: Book
• Published: BMC, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile ar...