Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

• Main Authors: Lan Chen (Author), Yuan Zhang (Author), Yi-Xin Zhang (Author), Wei-Lai Wang (Author), De-Mei Sun (Author), Peng-Yun Li (Author), Xue-Song Feng (Author), Yue Tan (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tyrosine kinase inhibitors (TKIs) have emerged as the first-line small molecule drugs in many cancer therapies, exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways. However, there exists a substantial inter-i...