Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

• Main Authors: Weilian Bao (Author), Jiaren Lyu (Author), Guize Feng (Author), Linfeng Guo (Author), Dian Zhao (Author), Keyuan You (Author), Yang Liu (Author), Haidong Li (Author), Peng Du (Author), Daofeng Chen (Author), Xiaoyan Shen (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post injury. Label retaining cells (LRCs) expressing SRY-box transcription factor 9 (SOX9) promote epithelial repair by replenishing LGR5+ intestinal stem cells (ISCs). Whil...