The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor.

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor.

Machupo virus (MACV), a New World arenavirus, is the etiological agent of Bolivian hemorrhagic fever (BHF). Junin virus (JUNV), a close relative, causes Argentine hemorrhagic fever (AHF). Previously, we reported that a recombinant, chimeric MACV (rMACV/Cd#1-GPC) expressing glycoprotein from the Cand...

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Main Authors: Takaaki Koma (Author), Cheng Huang (Author), Judith F Aronson (Author), Aida G Walker (Author), Milagros Miller (Author), Jeanon N Smith (Author), Michael Patterson (Author), Slobodan Paessler (Author)
Format: Book
Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
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