Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

• Main Authors: Zhendong Song (Author), Meijing Wang (Author), Yang Ge (Author), Xue-Ping Chen (Author), Ziyang Xu (Author), Yang Sun (Author), Xiao-Feng Xiong (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As a result of the low cell permeability and poor bioavailability, the traditional inhibitors targeting the protein tyrosine ph...