PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates

Uridine 5'-diphospho-glucuronosyltransferases (UGTs) are expressed in the small intestines, but prediction of first-pass extraction from the related metabolism is not well studied. This work assesses physiologically based pharmacokinetic (PBPK) modeling as a tool for predicting intestinal metab...

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Main Authors: Micaela B. Reddy (Author), Michael B. Bolger (Author), Grace Fraczkiewicz (Author), Laurence Del Frari (Author), Laibin Luo (Author), Viera Lukacova (Author), Amitava Mitra (Author), Joyce S. Macwan (Author), Jim M. Mullin (Author), Neil Parrott (Author), Aki T. Heikkinen (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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