An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

• Main Authors: Porreca Frank (Author), Shuster Sam J (Author), Huang Yuan-Yuan (Author), Ma Shou-Wu (Author), Zhang Dong-Qin (Author), Luo Miaw-Chyi (Author), Lai Josephine (Author)
• Format: Book
• Published: SAGE Publishing, 2005-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>We have developed a highly effective method for <it>in vivo </it>gene silencing in the spinal cord and dorsal root ganglia (DRG) by a cationic lipid facilitated delivery of synthetic, small interfering RNA (siRNA). A siRNA to the delta opioid receptor...