Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

• Päätekijät: Hae Jin Kee (Tekijä), Yuhee Ryu (Tekijä), Young Mi Seok (Tekijä), Sin Young Choi (Tekijä), Simei Sun (Tekijä), Gwi Ran Kim (Tekijä), Myung Ho Jeong (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: BMC, 2019-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Background The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate (DOCA) hypertension was attenuated by sodium valproate, a pan-HDAC inhi...