Protopine/Gemcitabine Combination Induces Cytotoxic or Cytoprotective Effects in Cell Type-Specific and Dose-Dependent Manner on Human Cancer and Normal Cells

• Main Authors: Mercedes Garcia-Gil (Author), Benedetta Turri (Author), Morena Gabriele (Author), Laura Pucci (Author), Alessandro Agnarelli (Author), Michele Lai (Author), Giulia Freer (Author), Mauro Pistello (Author), Robert Vignali (Author), Renata Batistoni (Author), Silvia Marracci (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The natural alkaloid protopine (PRO) exhibits pharmacological properties including anticancer activity. We investigated the effects of PRO, alone and in combination with the chemotherapeutic gemcitabine (GEM), on human tumor cell lines and non-tumor human dermal fibroblasts (HDFs). We found that tre...