Improved Quantification, Propagation, Purification and Storage of the Obligate Intracellular Human Pathogen Orientia tsutsugamushi.

• Main Authors: Suparat Giengkam (Author), Alex Blakes (Author), Peemdej Utsahajit (Author), Suwittra Chaemchuen (Author), Sharanjeet Atwal (Author), Stuart D Blacksell (Author), Daniel H Paris (Author), Nicholas P J Day (Author), Jeanne Salje (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Scrub typhus is a leading cause of serious febrile illness in rural Southeast Asia. The causative agent, Orientia tsutsugamushi, is an obligate intracellular bacterium that is transmitted to humans by the bite of a Leptotrombidium mite. Research into the basic mechanisms of cell biology a...