Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K+ Current in Rat Dorsal Root Ganglia

• Main Authors: Yoshiaki Ohishi (Author), Tomoya Matsutomi (Author), Taixing Zheng (Author), Jun-ichi Kakimura (Author), Hiroshi Maruyama (Author), Nobukuni Ogata (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effects of 4-aminopyridine (4-AP) on the transient K+ current (IA) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of IA was reduced by 4-AP. The steady-state inactivation curve for IA was shifted in the positive direction by 4-AP, suggesting that the blo...