Comprehensive genomic profiling of a unique liposarcoma arising in a patient with Li-Fraumeni syndrome and the novel detection of c-myc amplification: a case report

• Autores principales: Hirofumi Watanabe (Autor), Fumiyoshi Fujishima (Autor), Toru Motoi (Autor), Yayoi Aoyama (Autor), Tetsuya Niihori (Autor), Masanobu Takahashi (Autor), Sho Umegaki (Autor), Hisashi Oishi (Autor), Hiroshi Tada (Autor), Ryo Ichinohasama (Autor), Hironobu Sasano (Autor)
• Formato: Libro
• Publicado: BMC, 2022-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Germline TP53 mutations have been frequently reported in patients with Li-Fraumeni syndrome (LFS), resulting in a predisposition to various malignancies. Mutations other than germline TP53 mutations can also cause LFS-associated malignancies, but their details remain unclear. We...