A Citrulline‐Based Translational Population System Toxicology Model for Gastrointestinal‐Related Adverse Events Associated With Anticancer Treatments

• Главные авторы: Tomoki Yoneyama (Автор), Kojo Abdul‐Hadi (Автор), Adam Brown (Автор), Emily Guan (Автор), Matt Wagoner (Автор), Andy Z.X. Zhu (Автор)
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• Опубликовано: Wiley, 2019-12-01T00:00:00Z.
• Предметы: article
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Gastrointestinal (GI)‐related adverse events (AEs) are commonly observed in the clinic during cancer treatments. Citrulline is a potentially translatable biomarker of GI AEs. In this study, irinotecan‐induced citrulline changes were studied for a range of doses and schedules in rats. A translational...