Evaluation of the drug-drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach
Abstract Brigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK‐positive metastatic non‐small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P‐gp, BCRP, OCT1, MATE1, and MATE2K. Clini...
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Wiley,
2024-04-01T00:00:00Z.
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