Evaluation of the drug-drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach

• Main Authors: Michael J. Hanley (Author), Karen Rowland Yeo (Author), Meera Tugnait (Author), Shinji Iwasaki (Author), Narayana Narasimhan (Author), Pingkuan Zhang (Author), Karthik Venkatakrishnan (Author), Neeraj Gupta (Author)
• Format: Book
• Published: Wiley, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Brigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK‐positive metastatic non‐small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P‐gp, BCRP, OCT1, MATE1, and MATE2K. Clini...