Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice

• Main Authors: Bernhard N. Bohnert (Author), Irene Gonzalez-Menendez (Author), Thomas Dörffel (Author), Jonas C. Schneider (Author), Mengyun Xiao (Author), Andrea Janessa (Author), M. Zaher Kalo (Author), Birgit Fehrenbacher (Author), Martin Schaller (Author), Nicolas Casadei (Author), Kerstin Amann (Author), Christoph Daniel (Author), Andreas L. Birkenfeld (Author), Florian Grahammer (Author), Lahoucine Izem (Author), Edward F. Plow (Author), Leticia Quintanilla-Martinez (Author), Ferruh Artunc (Author)
• Format: Book
• Published: The Company of Biologists, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs. In addition, plasminogen (Plg) has been reported to play a rol...