Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma

• Main Authors: Damini Chand (Author), Yasuo Yamazaki (Author), Kristina Ruuth (Author), Christina Schönherr (Author), Tommy Martinsson (Author), Per Kogner (Author), Edward F. Attiyeh (Author), John Maris (Author), Olena Morozova (Author), Marco A. Marra (Author), Miki Ohira (Author), Akira Nakagawara (Author), Per-Erik Sandström (Author), Ruth H. Palmer (Author), Bengt Hallberg (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Neuroblastoma is a childhood extracranial solid tumour that is associated with a number of genetic changes. Included in these genetic alterations are mutations in the kinase domain of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK), which have been found in both somatic a...