Formulation and Development of Oral Fast-Dissolving Films Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers

• Autori principali: Ahmed Hassen Elshafeey (Autore), Rania Moataz El-Dahmy (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Paroxetine (PX) is the most potent serotonin reuptake inhibitor utilized in depression and anxiety treatment. It has drawbacks, such as having a very bitter taste, low water solubility, and undergoing extensive first pass metabolism, leading to poor oral bioavailability (<50%). This work aimed to...