Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophage

• Main Authors: Shuhua He (Author), Xiang Gu (Author), Jintong Yang (Author), Fei Xu (Author), Jiachun Hu (Author), Wei Wang (Author), Yiheng Huang (Author), Bin Lou (Author), Tingbo Ding (Author), Lu Zhou (Author), Deyong Ye (Author), Ker Yu (Author), Jibin Dong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the pancreatic cancer stroma and are related to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC) patients. Therefore, targeting tumor-associated macrophages is a possible strategy for the treatm...