RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions

• Main Authors: John Broad (Author), Nobuyuki Takahashi (Author), Masaomi Tajimi (Author), Masaki Sudo (Author), Adam Góralczyk (Author), Umesh Parampalli (Author), Kesava Mannur (Author), Toshinori Yamamoto (Author), Gareth J. Sanger (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim was to characterise RQ-00201894, a novel non-macrolide motilin agonist, using human recombinant receptors and then investigate its ability to facilitate cholinergic activity in human stomach. A reporter gene assay assessed motilin receptor function. Selectivity of action was determined using...