Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques

• Main Authors: Norbert Pardi (Author), Celia C. LaBranche (Author), Guido Ferrari (Author), Derek W. Cain (Author), István Tombácz (Author), Robert J. Parks (Author), Hiromi Muramatsu (Author), Barbara L. Mui (Author), Ying K. Tam (Author), Katalin Karikó (Author), Patricia Polacino (Author), Christopher J. Barbosa (Author), Thomas D. Madden (Author), Michael J. Hope (Author), Barton F. Haynes (Author), David C. Montefiori (Author), Shiu-Lok Hu (Author), Drew Weissman (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the enormous effort in the development of effective vaccines against HIV-1, no vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation of more effective anti-HIV vaccines is critically needed. Here we characterize the immune responses induced by nucleoside-...