Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations

• Main Authors: Yu Wang (Author), Xiaofen Liu (Author), Kun Li (Author), Yaxin Fan (Author), Jicheng Yu (Author), Hailan Wu (Author), Yi Li (Author), Xiaojie Wu (Author), Beining Guo (Author), Xin Li (Author), Jiali Hu (Author), Jufang Wu (Author), Guoying Cao (Author), Jing Zhang (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem. A randomized, single-dose, three-period, self-crossover controlled extended-infusion clinical trial was conducted with 12 healthy Chinese...