Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor preventing metastasis in triple-negative breast cancer cells

• Main Authors: Shasha Cheng (Author), Guan-Jun Yang (Author), Wanhe Wang (Author), Ying-Qi Song (Author), Chung-Nga Ko (Author), Quanbin Han (Author), Dik-Lung Ma (Author), Chung-Hang Leung (Author)
• Format: Book
• Published: Compuscript Ltd, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enhancer of zeste homolog 2 (EZH2) is activated in breast cancer, particularly in triple-negative breast cancer (TNBC), and is critical for cell invasion. It interacts with embryonic ectoderm development (EED) in maintaining cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT) propert...