Endoplasmic reticulum stress and quality control in relation to cisplatin resistance in tumor cells

• Main Authors: Wentao Mu (Author), Yao Zhi (Author), Jianpeng Zhou (Author), Chuanlei Wang (Author), Kaiyuan Chai (Author), Zhongqi Fan (Author), Guoyue Lv (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The endoplasmic reticulum (ER) is a crucial organelle that orchestrates key cellular functions like protein folding and lipid biosynthesis. However, it is highly sensitive to disturbances that lead to ER stress. In response, the unfolded protein response (UPR) activates to restore ER homeostasis, pr...