Design, synthesis, and bioevaluation of 1h-pyrrolo[3,2-c]pyridine derivatives as colchicine-binding site inhibitors with potent anticancer activities

• Hoofdauteurs: Chao Wang (Auteur), Yujing Zhang (Auteur), Shanbo Yang (Auteur), Lingyu Shi (Auteur), Rong Rong (Auteur), Tingting Zhang (Auteur), Yudong Wu (Auteur), Dongming Xing (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

AbstractA new series of 1H-pyrrolo[3,2-c]pyridine derivatives were designed and synthesised as colchicine-binding site inhibitors. Preliminary biological evaluations showed that most of the target compounds displayed moderate to excellent antitumor activities against three cancer cell lines (HeLa, S...